You’ve likely heard about IVF, IUI, and fertility medications—but what about the latest advancements in reproductive medicine?
Science is constantly evolving, and new fertility treatments are emerging that could increase egg quality, improve implantation, and boost pregnancy success rates—especially for women over 35.
Here are 10 promising fertility breakthroughs that many doctors might not be discussing yet!
1. Ovarian Rejuvenation with PRP (Platelet-Rich Plasma Therapy)
What It Is: PRP therapy involves injecting platelet-rich plasma (derived from your own blood) into the ovaries to stimulate follicle growth and egg production.
📌 Why It’s Promising:
- Early research shows PRP may help restore ovarian function in women with low ovarian reserve.
- Studies suggest PRP can increase AMH levels and antral follicle count.
🌿 Who It’s For: Women with low AMH, premature ovarian failure, or poor response to IVF.
2. Mitochondrial Replacement Therapy – “Recharging” Aging Eggs
🔋 What It Is: This technique extracts mitochondria (the energy-producing structures) from a woman’s younger stem cells and injects them into her eggs to improve energy levels.
📌 Why It’s Promising:
- Mitochondrial decline is a major cause of poor egg quality in women over 35.
- Early clinical trials showed higher embryo quality and increased pregnancy rates in women using this technique.
🌿 Who It’s For: Women with poor embryo quality, repeated IVF failures, or advanced maternal age.
3. Stem Cell Therapy for Ovarian Function
What It Is: Scientists are exploring stem cell injections into the ovaries to help regenerate egg-producing cells and improve ovarian function.
📌 Why It’s Promising:
- Studies have found that mesenchymal stem cells improve ovarian function in women with diminished ovarian reserve.
- Researchers believe stem cells could one day restore fertility in women with early menopause.
🌿 Who It’s For: Women with low ovarian reserve, early menopause, or diminished egg quality.
4. Artificial Intelligence (AI) for Embryo Selection
What It Is: AI-based technology now helps embryologists analyze embryo quality more accurately, improving IVF success rates.
📌 Why It’s Promising:
- Traditional embryo grading is done manually, but AI can detect subtle patterns that the human eye may miss.
- AI-driven embryo selection has been linked to higher implantation and pregnancy rates.
🌿 Who It’s For: Women undergoing IVF who want the best possible embryo selection for implantation.
5. Uterine “Scratch” Therapy for Improved Implantation
What It Is: A mild scraping of the uterine lining (endometrial scratch) before embryo transfer to increase implantation success.
📌 Why It’s Promising:
- The “micro-injury” triggers a healing response, making the uterine lining more receptive to an embryo.
- Studies show that uterine scratch therapy can significantly improve pregnancy rates in IVF patients.
🌿 Who It’s For: Women with repeated implantation failure or thin endometrial lining.
6. Low-Level Laser Therapy (LLLT) for Egg & Uterine Health
What It Is: Red light therapy (LLLT) is applied to the lower abdomen to improve blood flow to the ovaries and uterus.
📌 Why It’s Promising:
- LLLT increases ATP (cellular energy) production, potentially improving egg quality.
- A clinical study found that women with poor ovarian response had higher pregnancy rates after LLLT treatment.
🌿 Who It’s For: Women with low ovarian reserve, poor egg quality, or thin uterine lining.
7. DHEA & CoQ10 for Egg Quality Optimization
What It Is: DHEA (a mild androgen) and CoQ10 (a mitochondrial booster) are two of the most well-researched supplements for improving egg quality.
📌 Why It’s Promising:
- Studies show DHEA improves egg count and embryo quality in women with diminished ovarian reserve.
- CoQ10 boosts mitochondrial function in eggs, increasing fertility success rates.
CoQ10 is something that I took daily on my fertility journey and still take today. See my list of fertility supplements here.
🌿 Who It’s For: Women over 35 looking to improve egg quality naturally.
8. Acupuncture + Traditional Chinese Medicine (TCM) for Hormone Balance
What It Is: Acupuncture enhances blood flow to the reproductive organs, improves hormonal balance, and reduces stress.
📌 Why It’s Promising:
- Acupuncture has been shown to increase IVF success rates by up to 65% when done before and after embryo transfer.
- TCM herbs like Dang Gui and Goji Berry extract support uterine health and hormone regulation.
🌿 Who It’s For: Women who want a natural, holistic approach to fertility. See more on acupuncture for fertility here!
9. Ovarian Tissue Transplantation for Fertility Preservation
What It Is: A newer technique where a small piece of ovarian tissue is removed, frozen, and later transplanted back to restore fertility.
📌 Why It’s Promising:
- This has allowed women who went through early menopause to conceive naturally.
- It could become a powerful tool for fertility preservation.
🌿 Who It’s For: Women at risk of early menopause or undergoing chemotherapy.
10. The “Fertility Microbiome” & Probiotics for Implantation Success
What It Is: The gut and vaginal microbiome impact fertility, and emerging research suggests that probiotics may enhance implantation.
📌 Why It’s Promising:
- Studies have found that women with a healthy uterine microbiome had higher pregnancy success rates.
- Probiotics like Lactobacillus crispatus may help support implantation.
🌿 Who It’s For: Women with unexplained infertility or recurrent implantation failure.
How to Find Clinics Offering These New Fertility Treatments
Not all fertility clinics offer these cutting-edge treatments yet, but more are beginning to adopt them as research continues to grow. Here’s how you can find clinics and specialists who provide these advanced options.
1. Search for Clinics Specializing in Reproductive Innovation
💡 Many large fertility centers and research-based clinics offer experimental and advanced treatments. When searching, look for clinics that mention:
🔹 “Regenerative reproductive medicine”
🔹 “Stem cell therapy for fertility”
🔹 “Ovarian rejuvenation”
🔹 “Advanced embryo selection” (AI-based)
🌿 Where to Start:
✔️ FertilityIQ – (www.fertilityiq.com) – A site with patient reviews of fertility clinics & treatments.
✔️ The American Society for Reproductive Medicine (ASRM) – (www.asrm.org) – Lists accredited clinics and cutting-edge fertility research.
✔️ Resolve: The National Infertility Association – (www.resolve.org) – A great resource for finding fertility specialists.
2. Look for Clinical Trials & Research Studies
Many of the most exciting new fertility treatments are being tested in clinical trials, and some offer free or discounted treatments in exchange for participation.
🌿 Where to Start:
✔️ ClinicalTrials.gov – (www.clinicaltrials.gov) – Search for “fertility” + “PRP,” “stem cells,” or “ovarian rejuvenation.”
✔️ NIH Clinical Research Studies – (www.researchmatch.org) – Connects patients to fertility studies.
3. Ask Your Fertility Doctor About Emerging Treatments
Even if your clinic doesn’t offer PRP, Augment™, or AI embryo selection, they may be able to refer you to a specialist who does.
🌿 Questions to Ask Your Doctor:
✔️ “Do you offer ovarian rejuvenation treatments like PRP or stem cell therapy?”
✔️ “What are my options for improving egg quality beyond traditional IVF?”
✔️ “Do you use AI-based embryo selection for IVF?”
💡 Tip: If your doctor isn’t familiar with these treatments, bring research articles (PubMed links work well!) to start the conversation.
4. Connect with Other Women in Fertility Communities
Sometimes, the best recommendations come from other women who have already tried these treatments.
🌿 Where to Find Support:
✔️ Facebook Groups – Search for:
- “Ovarian Rejuvenation & PRP for Fertility”
- “Advanced Fertility Treatments Over 35”
✔️ Fertility Forums – Check out: - FertilityFriend.com
- IVFConnections.com
✔️ Instagram & TikTok – Many women share their fertility journeys and new treatments using hashtags like #OvarianRejuvenation #IVFBreakthroughs.
5. Look for Specialized Clinics Offering Cutting-Edge Treatments
Some clinics specialize in advanced fertility therapies, including PRP, Augment™, AI embryo selection, and stem cell treatments.
🌿 Clinics Known for Fertility Innovation:
📍 CNY Fertility (USA) – Offers PRP, stem cell research, and integrative approaches.
📍 Ovation Fertility (USA) – Uses AI embryo selection & advanced IVF techniques.
📍 Create Fertility (UK & USA) – Focuses on mild IVF, ovarian rejuvenation, and PRP.
📍 Fertility Institute of Hawaii (USA) – Researching mitochondrial replacement therapy (Augment™).
💡 Tip: Many clinics offer virtual consultations, so even if they’re not in your area, you can still explore your options!
Final Thoughts: You Have More Options Than Ever
Fertility treatments are evolving quickly, and you don’t have to settle for outdated advice that says, “it’s too late.”
💖 Science is on your side.
💖 More options exist today than ever before.
💖 Your baby is still waiting for you—and breakthroughs are making it possible.
🌸 Which of these treatments excites you the most? Let’s talk in the comments! 💕✨
Further Reading
The effect of ovarian injection of autologous platelet rich plasma in patients with poor ovarian responder – Frontiers in Endocrinology
Mitochondrial Transfer into Human Oocytes Improved Embryo Quality and Clinical Outcome – NIH
Stem cell-based therapeutic potential in female ovarian aging and infertility – Journal of Ovarian Research
The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health – Journal of Clinical Medicine
What Is Ovarian Tissue Cryopreservation and Transplantation and How Successful Is the Procedure? – FertilityPreservation.org
Lactobacillus crispatus-dominated vaginal microbiome and Acinetobacter-dominated seminal microbiome support beneficial ART outcome – Wiley’s Obstetrics & Gynecology Hub